miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

The influence of miR-221 on TRAIL-mediated apoptosis is highly context- and entity-dependent.

miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo

These data support a tumor suppressive role of miR-221-5p in the context of PCa and its potential as therapeutic target.