Prostate cancer

Patient-derived xenografts and organoids model therapy response in prostate cancer

This proof-of-principle study provides a preclinical tool to screen drug responses to standard-of-care and newly identified, repurposed compounds.

Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures

In this study we show that metastatic PCa PDXs, which differ in androgen sensitivity, trigger differential stroma responses, which show the metastasis risk stratification and prognostic biomarker potential.

Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

In this study we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), sensitize therapy refractory models of PCa to radio, chemo or hormonal treatment.

Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions

In this study we investigate the association between TRPM4 and Prostate Cancer.

Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bone microenvironment signatures

Selected stromal markers of osteoblastic PCa indicate a conserved mechanism of tumor cells to induce a stromal pre-metastatic signature with high potential prognostic or diagnostic value.

Patient-derived xenografts and organoids model therapy response in prostate cancer

This proof-of-principle study provides a preclinical tool to screen drug responses to standard-of-care and newly identified, repurposed compounds.

Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification

In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence, with the aim of improving patient stratification.

miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

The influence of miR-221 on TRAIL-mediated apoptosis is highly context- and entity-dependent.

miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo

These data support a tumor suppressive role of miR-221-5p in the context of PCa and its potential as therapeutic target.

Therapeutic Targeting of CD146/MCAM Reduces Bone Metastasis in Prostate Cancer

This study highlights the functional application of an anti-MCAM mAb to target prostate cancer bone metastasis.