In this review we focused on the modulation of TMPRSS2-ERG and Glucocorticoid Receptor (GR) by microRNAs and detailed the influence of steroidal hormonal therapies on microRNAs expression.
This study highlights a functional role for CRIPTO and GRP78 in PCa metastasis and suggest that targeting CRIPTO/GRP78 signaling may have significant therapeutic potential.
In this review we present describe the role of miRs in the processing of the supportive bone microenvironment prior and after the bone colonization by cancer cells. Finally, future therapeutic strategies and perspectives are also discussed.
Our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with αv- and α6-integrin expression.