Prostate cancer

Metastases in Prostate Cancer

A book chapter focused on the biological processess involved in the progression from primary to metastatic disease in prostate cancer.

Emerging aspects of microRNA interaction with TMPRSS2-ERG and endocrine therapy

In this review we focused on the modulation of TMPRSS2-ERG and Glucocorticoid Receptor (GR) by microRNAs and detailed the influence of steroidal hormonal therapies on microRNAs expression.

ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models

This study supports the validity of ongoing clinical development of drugs blocking ALK1 and ALK2 receptor activity.

Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives

This review focuses on SOCE component dysregulation in prostate cancer and analyzes several preclinical, cellular, and animal cancer research models.

CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer

This study highlights a functional role for CRIPTO and GRP78 in PCa metastasis and suggest that targeting CRIPTO/GRP78 signaling may have significant therapeutic potential.

A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response

This review delineates the zebrafish CSC-xenograft model as a useful tool for both CSC biological study and anticancer drug screening.

The role of microRNAs in bone metastasis

In this review we present describe the role of miRs in the processing of the supportive bone microenvironment prior and after the bone colonization by cancer cells. Finally, future therapeutic strategies and perspectives are also discussed.

My PhD thesis in a small book

In Holland the PhD thesis are published as small real books

miR-25, integrin and cancer invasiveness

This editorial summarizes our previous findings that miR-25 directly targets ITGAV and ITGA6.

miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression

Our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with αv- and α6-integrin expression.